https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30085 Wed 24 Nov 2021 15:50:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33190 6 s region resulted in higher prognostic value than recanalization at predicting good clinical outcome (area under the curve = 0.88 and 0.74, respectively, p = 0.002). Successful reperfusion of the Tmax>6 s region (≥60%) had 89% sensitivity and 78% specificity in predicting good clinical outcome. A reperfusion index defined by Tmax>2 s or by mean transit time>145% had much lower area under the curve in comparison to Tmax>6 s measurement (p < 0.001 and p = 0.003, respectively), and had no significant difference to recanalization at predicting clinical outcome (p = 0.58 and 0.63, respectively). In conclusion, reperfusion index calculated by Tmax>6 s is a stronger predictor of clinical outcome than recanalization or other reperfusion measures.]]> Wed 23 Feb 2022 16:03:42 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31334 Wed 23 Feb 2022 16:02:54 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32497 Wed 17 Nov 2021 16:32:12 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16985 Wed 11 Apr 2018 15:07:10 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22101 Wed 11 Apr 2018 10:59:34 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16993 450% immediately after MCAo. Collateral diameter changed minimally. Second, we determined the effect of ICP elevation on collateral and watershed penetrating arteriole flow. Intracranial pressure was artificially raised in stepwise increments during MCAo. The ICP increase was strongly correlated with collateral and penetrating arteriole flow reductions. Changes in collateral flow post-stroke appear to be primarily driven by the pressure drop across the collateral vessel, not vessel diameter. The ICP elevation reduces cerebral perfusion pressure and collateral flow, and is the possible explanation for 'collateral failure' in stroke-in-progression.]]> Wed 11 Apr 2018 09:23:28 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32689 Wed 10 Nov 2021 15:04:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48308 2Y₁₂ was present on non-responsive microglia in the first two weeks after stroke but not at later time points. Finally, both classical microglia activation and loss of process extension are highly correlated with neuronal damage. Our findings highlight the importance of microglia, specifically microglia dynamic functions, to the progression of SND post-stroke, and their potential relevance as modulators or therapeutic targets during stroke recovery.]]> Tue 14 Mar 2023 14:41:54 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44277 5 s (AUC: 0.80) in GM and T max > 7 s (AUC: 0.75) in WM. With sSVD, a delay time (DT) > 3 s from ddSVD was the optimal for both GM (AUC: 0.78) and WM (AUC: 0.75). Using tissue-specific thresholds for GM/WM provides more accurate estimation of acute ischemic core.]]> Tue 11 Oct 2022 14:27:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48143 Tue 07 Mar 2023 11:18:54 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43876 Tue 04 Oct 2022 12:35:43 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24301 Thu 28 Oct 2021 12:36:50 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42682 Thu 01 Sep 2022 08:45:21 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10901 190 mL). Excellent outcome from tPA treatment was substantially increased in patients with DWI lesions < 18mL (77% versus 18% placebo, OR= 15.0, P < 0.001). Benefit from tPA was also seen with DWI lesions up to 25mL (69% versus 29% placebo, OR= 5.5, P= 0.03), but not for DWI lesions > 25 mL. In contrast, increasing mismatch ratios did not influence the odds of excellent outcome with tPA. Clinical responsiveness to IV-tPA, and stroke outcome, depends more on baseline DWI and PWI lesion volumes than the extent of perfusion–diffusion mismatch.]]> Sat 24 Mar 2018 08:09:03 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18166 50% of neurons within the sample. To determine whether FMISO retention occurred after the tissue was already committed to infarction, FMISO was administered 4 to 6 hours after the onset of permanent vessel occlusion. Intense FMISO retention was consistently seen throughout the infarct core. In conclusion, FMISO retention occurs both within the ischaemic penumbra and within the early infarct core. Most penumbral tissues show evidence of selective cellular injury.]]> Sat 24 Mar 2018 08:04:38 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20340 6 seconds, ratio>1.2) in 3/119 (2.5%) patients. Diffusion lesion reversal between baseline and 3 to 6 hours DWI was also uncommon (7/65, 11%) and often transient. Clinically relevant DLR is uncommon and rarely alters perfusion-diffusion mismatch. The acute diffusion lesion is generally a reliable signature of the infarct core.]]> Sat 24 Mar 2018 08:02:57 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20536 Sat 24 Mar 2018 08:02:43 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20363 Sat 24 Mar 2018 07:58:13 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21296 Sat 24 Mar 2018 07:54:39 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19728 P<0.001) and smaller baseline diffusion lesion volume (Rho −0.70, P<0.001). In 30 patients without reperfusion at day 3 to 5, deterioration in collateral quality between baseline and subacute imaging was strongly associated with absolute (P=0.02) and relative (P<0.001) infarct growth. The deterioration in collateral grade correlated with increased mean Tmax hypoperfusion severity (Rho −0.68, P<0.001). Deterioration in Tmax hypoperfusion severity was also significantly associated with absolute (P=0.003) and relative (P=0.002) infarct growth. Collateral flow is dynamic and failure is associated with infarct growth.]]> Sat 24 Mar 2018 07:53:45 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49555 Mon 22 May 2023 09:13:41 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46183 Mon 14 Nov 2022 10:13:02 AEDT ]]>